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Addison's Disease

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NORD is very grateful to Maria I. New, MD, Professor of Pediatrics and Human Genetics and Director of Adrenal Steroid Disorders Program, Mount Sinai School of Medicine, for assistance in the preparation of this report.

Synonyms of Addison's Disease
  • Chronic Adrenocortical Insufficiency
  • Primary Adrenal Insufficiency
  • Primary Failure Adrenocortical Insufficiency

Disorder Subdivisions



General Discussion
Addison’s disease is a rare disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the outer layer of cells of the adrenal glands (adrenal cortex). The symptoms of classic Addison’s disease, also known as primary adrenal insufficiency, result from the insufficient production of these two hormones. Major symptoms include fatigue, gastrointestinal abnormalities, and changes in skin color (pigmentation). Behavior and mood changes may also occur in some individuals with Addison’s disease. Increased excretion of water and low blood pressure (hypotension) can lead to extremely low concentrations of water in the body (dehydration). The symptoms of Addison’s usually develop slowly, but sometimes can develop rapidly, a serious condition called acute adrenal failure. In most cases, Addison’s disease occurs when the body’s immune system mistakenly attacks the adrenal glands causing slowly progressive damage to the adrenal cortex.
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Organizations related to Addison's Disease
  • Addison's Disease Self-Help Group (UK)
    P.O. Box 1083
    Guildford, Surrey None GU1 9HX
    Phone #: 084-4 5-88 2722
    800 #: N/A
    e-mail: info@addisons.org.uk
    Home page: http://www.addisons.org.uk
  • American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Avenue
    Eastpointe MI 48021
    Phone #: 586-776-3900
    800 #: 800-598-4668
    e-mail: aarda@aarda.org
    Home page: http://www.aarda.org/
  • AutoImmunity Community
    None
    None None None
    Phone #: (91-9) -552-9057
    800 #: N/A
    e-mail: moderator@autoimmunitycommunity.org
    Home page: http://www.autoimmunitycommunity.org
  • Autoimmune Information Network, Inc
    PO Box 4121
    Brick NJ 08723
    Phone #: 732-664-9259
    800 #: N/A
    e-mail: autoimmunehelp@aol.com
    Home page: http://www.aininc.org
  • Congenital Adrenal Hyperplasia Support Group
    PO Box 66
    Waihi
    Hauraki None 3641
    Phone #: +64- 3 -3584 507
    800 #: 080-0 2-24 698
    e-mail: CAHNZ@snap.net.nz
    Home page: http://www.cah.org.nz/
  • Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg MD 20898-8126
    Phone #: 301-251-4925
    800 #: 888-205-2311
    e-mail: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
    Home page: http://rarediseases.info.nih.gov/GARD
  • Hormone Foundation
    8401 Connecticut Avenue
    Suite 900
    Chevy Chase MD 20815-5817
    Phone #: --
    800 #: 800-467-6663
    e-mail: hormone@endo-society.org
    Home page: http://www.hormone@endo-society.org
  • MUMS National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: mums@netnet.net
    Home page: http://www.netnet.net/mums/
  • MedicAlert Foundation International
    2323 Colorado Avenue
    Turlock CA 95382
    Phone #: 209-669-2401
    800 #: 888-633-4298
    e-mail: Inquiries@medicalert.org
    Home page: http://www.medicalert.org
  • NIH/National Digestive Diseases Information Clearinghouse
    2 Information Way
    Bethesda MD 20892-3570
    Phone #: 301-654-3810
    800 #: 800-891-5389
    e-mail: nddic@info.niddk.nih.gov
    Home page: http://www.niddk.nih.gov
  • National Adrenal Diseases Foundation
    505 Northern Boulevard
    Great Neck NY 11021
    Phone #: 516-487-4992
    800 #: --
    e-mail: NADFmail@aol.com
    Home page: http://www.nadf.us/

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Last modified Tuesday, September 07, 2010